Five infusions over two weeks. Here is exactly what each one feels like, how we keep you comfortable, how to prepare — and an honest word on what the science does and does not promise.
Book a Consultation What it feels likeNAD+ — nicotinamide adenine dinucleotide — is a coenzyme every cell uses to turn fuel into energy and to run its repair machinery. Levels decline with age. The loading series is the front-loaded part of restoring them: five intravenous infusions of 750 mg, spaced across roughly two weeks. After loading, most patients transition to a lower-effort subcutaneous maintenance dose at home — 100 to 200 mg, daily or every other day — which keeps cellular stores topped up without returning to the chair.
The reason for the loading-then-maintenance shape is practical pharmacology. Intravenous delivery raises circulating NAD+ quickly; the clustered loading infusions establish the baseline, and maintenance holds it there. This page is about the loading two weeks specifically — the part that is new to you.
Each NAD+ infusion runs roughly 2 to 3 hours. NAD+ is delivered slowly on purpose — that is what keeps it comfortable. Plan the visit like an appointment with a book, not an errand. Do not schedule it tight against something you cannot be late for.
The single most important thing to know before your first infusion: NAD+ given intravenously produces a set of sensations that are expected pharmacology, not an adverse reaction. Knowing this in advance is most of what makes the first visit easy.
Many patients feel warmth move through the chest, face, or whole body. It rises, plateaus, and settles. It is the most common sensation and the most benign.
A mild "pressure," tightness, or fluttery feeling can accompany the warmth. It is dose-rate dependent — it tracks how fast the NAD+ is going in.
This is the whole trick. The instant a sensation becomes more than mild, we reduce the infusion rate. Within a minute or two it eases. You are in control of the pace, and we will tell you that out loud.
Some patients notice transient stomach awareness or a light head if the rate is high. Same fix — slow down, sip water, breathe. It passes. Tell your nurse the moment you feel anything; that is what they are there for.
There is no prize for finishing fast. A comfortable three-hour infusion is a better infusion than a rushed two-hour one. The drip rate is a dial, not a fixed setting — and it is set to you.
Responses vary — this is a typical arc, not a guarantee. Some patients feel a lift early; many notice the difference most clearly in the days after the series ends, once stores are full.
The orientation visit. You learn your comfortable drip rate. Expect the warmth and flush; expect to finish a little tired. Hydrate after.
Familiar now. The flush is usually easier the second time because you know what it is. Some patients report steadier energy between visits 1 and 2.
Midpoint. This is where many patients first describe clearer focus or a more even mood. Equally normal to feel nothing distinct yet.
Routine. The chair time feels shorter. Sleep quality is the change patients mention most often by this point.
Series complete. Stores are loaded. We set up your subcutaneous maintenance plan so the gains hold — and review how you actually felt.
Week 1 (infusions 1–3) is mostly about getting comfortable with the process and finding your rate. Week 2 (infusions 4–5) is where subjective changes — energy, sleep, focus — are most commonly reported. If you feel nothing dramatic, that is within the normal range too; NAD+ is a substrate, not a stimulant.
Tell your nurse about any prior IV reactions, your medication list, and anything that makes you anxious about needles or infusions. None of it is a problem; all of it helps us pace your visit well.
Limitless is a physician-led practice, and that means you get the real version, not the marketing version.
The cell biology of NAD+ is well established — it is genuinely central to mitochondrial energy production and DNA-repair pathways, and levels genuinely fall with age. Intravenous and precursor studies reliably raise measurable NAD+. Early 2026 research, including a major expert review in Nature Aging and work on fatigue states, is encouraging on energy, sleep, and recovery.
What the evidence does not yet show is a proven anti-aging or disease-prevention outcome in humans — the large, long, hard-endpoint trials simply do not exist yet, and a 2026 systematic review said exactly that. NAD+ IV is not an FDA-approved treatment for aging or any wellness indication. We prescribe it as Dr. Hare's considered longevity intervention, with that uncertainty stated plainly. If you want the full picture, read our NAD+ clinical-evidence brief — the same honest map, in depth.
Set your expectations accordingly: most patients describe better energy, sleep, and mental clarity. That is a reasonable thing to hope for. A guarantee of reversed aging is not — and any clinic that offers you one is selling, not practicing medicine.
Every NAD+ protocol at Limitless begins with a physician visit — so the plan fits your physiology, not a package tier. The first twenty-five founding members lock pricing for 24 months, receive a complimentary NAD+ loading protocol (5×750 mg over their first two weeks), keep lifetime 10% off membership, and earn direct portal access to Dr. Hare.
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